Mirtazapinum [Inn-Latin]
Brand names,
Mirtazapinum [Inn-Latin]
Analogs
Mirtazapinum [Inn-Latin]
Brand Names Mixture
Mirtazapinum [Inn-Latin]
Chemical_Formula
C17H19N3
Mirtazapinum [Inn-Latin]
RX_link
http://www.rxlist.com/cgi/generic/mirtaz.htm
Mirtazapinum [Inn-Latin]
fda sheet
Mirtazapinum [Inn-Latin]
msds (material safety sheet)
Mirtazapinum [Inn-Latin]
Synthesis Reference
W. J. Van der Burg, U.S. Pat. 4,062,848 (1977)
Mirtazapinum [Inn-Latin]
Molecular Weight
265.353 g/mol
Mirtazapinum [Inn-Latin]
Melting Point
114-116oC
Mirtazapinum [Inn-Latin]
H2O Solubility
Slight
Mirtazapinum [Inn-Latin]
State
Solid
Mirtazapinum [Inn-Latin]
LogP
2.369
Mirtazapinum [Inn-Latin]
Dosage Forms
Tablet; Tablet (orally disintegrating)
Mirtazapinum [Inn-Latin]
Indication
For the treatment of major depressive disorder.
Mirtazapinum [Inn-Latin]
Pharmacology
Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.
Mirtazapinum [Inn-Latin]
Absorption
Rapid and complete, but, due to first-pass metabolism, absolute bioavailability is 50%.
Mirtazapinum [Inn-Latin]
side effects and Toxicity
Symptoms of overdose include disorientation, drowsiness, impaired memory, and tachycardia. LD50=mg/kg (orally in rat).
Mirtazapinum [Inn-Latin]
Patient Information
Mirtazapinum [Inn-Latin]
Organisms Affected
Humans and other mammals